Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Phosphotidylinositol-3-kinase (PI3K) signaling is altered in the majority of human cancers. To gain insight into the roles of members of this pathway in growth regulation, we inactivated AKT1, AKT2, or PDPK1 genes by targeted homologous recombination in human colon cancer cell lines. Knockout of eit...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ericson, Kajsa, Gan, Christine, Cheong, Ian, Rago, Carlo, Samuels, Yardena, Velculescu, Victor E., Kinzler, Kenneth W., Huso, David L., Vogelstein, Bert, Papadopoulos, Nickolas
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2010
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823889/
https://ncbi.nlm.nih.gov/pubmed/20133737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914018107
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