Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Phosphotidylinositol-3-kinase (PI3K) signaling is altered in the majority of human cancers. To gain insight into the roles of members of this pathway in growth regulation, we inactivated AKT1, AKT2, or PDPK1 genes by targeted homologous recombination in human colon cancer cell lines. Knockout of eit...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ericson, Kajsa, Gan, Christine, Cheong, Ian, Rago, Carlo, Samuels, Yardena, Velculescu, Victor E., Kinzler, Kenneth W., Huso, David L., Vogelstein, Bert, Papadopoulos, Nickolas
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823889/
https://ncbi.nlm.nih.gov/pubmed/20133737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914018107
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires