Evaluating the evaluation of cancer driver genes

Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have been developed to identify driver genes, but evaluation of the performance of these methods is hindered by the lack of a gold standard, th...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tokheim, Collin J., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Karchin, Rachel
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167163/
https://ncbi.nlm.nih.gov/pubmed/27911828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616440113
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