Cancer-specific High-throughput Annotation of Somatic Mutations: computational prediction of driver missense mutations

Large-scale sequencing of cancer genomes has uncovered thousands of DNA alterations, but the functional relevance of the majority of these mutations to tumorigenesis is unknown. We have developed a computational method, called CHASM (Cancer-specific High-throughput Annotation of Somatic Mutations),...

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Hauptverfasser: Carter, Hannah, Chen, Sining, Isik, Leyla, Tyekucheva, Svitlana, Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Karchin, Rachel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763410/
https://ncbi.nlm.nih.gov/pubmed/19654296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1133
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