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Accumulation of driver and passenger mutations during tumor progression

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the current study, we provide a mathematical model that begins...

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Hlavní autoři: Bozic, Ivana, Antal, Tibor, Ohtsuki, Hisashi, Carter, Hannah, Kim, Dewey, Chen, Sining, Karchin, Rachel, Kinzler, Kenneth W., Vogelstein, Bert, Nowak, Martin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972991/
https://ncbi.nlm.nih.gov/pubmed/20876136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010978107
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