Challenges and Perspectives for Therapeutic Targeting of Myeloproliferative Neoplasms

Por Brkic, Sime, Meyer, Sara C.
Publicado no Hemasphere (2020)

Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors

Por Meyer, Sara C., Levine, Ross L.
Publicado em 2014

Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera

Por Meyer, Sara C., Steinmann, Eva, Lehmann, Thomas, Muesser, Patricia, Passweg, Jakob R., Skoda, Radek C., Tsakiris, Dimitrios A.
Publicado no Biomed Res Int (2017)

Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis

Por Meyer, Sara C., Keller, Matthew D., Woods, Brittany A., LaFave, Lindsay M., Bastian, Lennart, Kleppe, Maria, Bhagwat, Neha, Marubayashi, Sachie, Levine, Ross L.
Publicado em 2014

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Por Nitulescu, Ioana I., Meyer, Sara C., Wen, Qiang Jeremy, Crispino, John D., Lemieux, Madeleine E., Levine, Ross L., Pelish, Henry E., Shair, Matthew D.
Publicado no EBioMedicine (2017)

Amotosalen/ultraviolet A pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance

Por Stivala, Simona, Gobbato, Sara, Infanti, Laura, Reiner, Martin F., Bonetti, Nicole, Meyer, Sara C., Camici, Giovanni G., Lüscher, Thomas F., Buser, Andreas, Beer, Jürg H.
Publicado no Haematologica (2017)

In response to the comment by Hechler et al.: Amotosalen/UVA pathogen inactivation technology reduces platelet activatability, induces apoptosis and accelerates clearance.

Por Stivala, Simona, Gobbato, Sara, Infanti, Laura, Reiner, Martin F., Bonetti, Nicole, Meyer, Sara C., Camici, Giovanni G., Lüscher, Thomas F., Buser, Andreas, Beer, Juerg H.
Publicado no Haematologica (2017)

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Por Kunimoto, Hiroyoshi, Meydan, Cem, Nazir, Abbas, Whitfield, Justin, Shank, Kaitlyn, Rapaport, Franck, Maher, Rebecca, Pronier, Elodie, Meyer, Sara C., Garrett-Bakelman, Francine E., Tallman, Martin, Melnick, Ari, Levine, Ross L., Shih, Alan H.
Publicado no Cancer Cell (2017)

Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis

Por Shimizu, Takafumi, Kubovcakova, Lucia, Nienhold, Ronny, Zmajkovic, Jakub, Meyer, Sara C., Hao-Shen, Hui, Geier, Florian, Dirnhofer, Stephan, Guglielmelli, Paola, Vannucchi, Alessandro M., Feenstra, Jelena D. Milosevic, Kralovics, Robert, Orkin, Stuart H., Skoda, Radek C.
Publicado no J Exp Med (2016)

Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms

Por Stivala, Simona, Codilupi, Tamara, Brkic, Sime, Baerenwaldt, Anne, Ghosh, Nilabh, Hao-Shen, Hui, Dirnhofer, Stephan, Dettmer, Matthias S., Simillion, Cedric, Kaufmann, Beat A., Chiu, Sophia, Keller, Matthew, Kleppe, Maria, Hilpert, Morgane, Buser, Andreas S., Passweg, Jakob R., Radimerski, Thomas, Skoda, Radek C., Levine, Ross L., Meyer, Sara C.
Publicado no J Clin Invest (2019)

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Por Waibel, Michaela, Solomon, Vanessa S., Knight, Deborah A., Ralli, Rachael A., Kim, Sang-Kyu, Banks, Kellie-Marie, Vidacs, Eva, Virely, Clemence, Sia, Keith C.S., Bracken, Lauryn S., Collins-Underwood, Racquel, Drenberg, Christina, Ramsey, Laura B., Meyer, Sara C., Takiguchi, Megumi, Dickins, Ross A., Levine, Ross, Ghysdael, Jacques, Dawson, Mark A., Lock, Richard B., Mullighan, Charles G., Johnstone, Ricky W.
Publicado em 2013

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms

Por Meyer, Sara C., Keller, Matthew D., Chiu, Sophia, Koppikar, Priya, Guryanova, Olga A., Rapaport, Franck, Xu, Ke, Manova, Katia, Pankov, Dmitry, O’Reilly, Richard J., Kleppe, Maria, McKenney, Anna Sophia, Shih, Alan H., Shank, Kaitlyn, Ahn, Jihae, Papalexi, Eftymia, Spitzer, Barbara, Socci, Nick, Viale, Agnes, Mandon, Emeline, Ebel, Nicolas, Andraos, Rita, Rubert, Joëlle, Dammassa, Ernesta, Romanet, Vincent, Dölemeyer, Arno, Zender, Michael, Heinlein, Melanie, Rampal, Rajit, Weinberg, Rona Singer, Hoffman, Ron, Sellers, William R., Hofmann, Francesco, Murakami, Masato, Baffert, Fabienne, Gaul, Christoph, Radimerski, Thomas, Levine, Ross L.
Publicado no Cancer Cell (2015)