Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on tyrosine phosphorylation of STATs, but the role of...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Nitulescu, Ioana I., Meyer, Sara C., Wen, Qiang Jeremy, Crispino, John D., Lemieux, Madeleine E., Levine, Ross L., Pelish, Henry E., Shair, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832629/
https://ncbi.nlm.nih.gov/pubmed/29239838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.11.013
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