Kinase signaling and targeted therapy for primary myelofibrosis

por Yang, Qiong, Crispino, John D, Wen, Qiang Jeremy
Publicado en Exp Hematol (2016)

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation

por Goldenson, Benjamin, Kirsammer, Gina, Stankiewicz, Monika J., Wen, Qiang Jeremy, Crispino, John D.
Publicado en Blood (2015)

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

por Nitulescu, Ioana I., Meyer, Sara C., Wen, Qiang Jeremy, Crispino, John D., Lemieux, Madeleine E., Levine, Ross L., Pelish, Henry E., Shair, Matthew D.
Publicado en EBioMedicine (2017)

Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo

por Woods, Brittany, Chen, Wei, Chiu, Sophia, Marinaccio, Christian, Fu, Chunling, Gu, Lilly, Bulic, Marinka, Yang, Qiong, Zouak, Anouar, Jia, Shengxian, Suraneni, Praveen Kumar, Xu, Kailin, Levine, Ross L., Crispino, John D., Wen, Qiang Jeremy
Publicado en Clin Cancer Res (2019)

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2(V617F)-positive myeloproliferative neoplasms

por Zhao, Baobing, Mei, Yang, Cao, Lan, Zhang, Jingxin, Sumagin, Ronen, Yang, Jing, Gao, Juehua, Schipma, Matthew J., Wang, Yanfeng, Thorsheim, Chelsea, Zhao, Liang, Stalker, Timothy, Stein, Brady, Wen, Qiang Jeremy, Crispino, John D., Abrams, Charles S., Ji, Peng
Publicado en J Clin Invest (2017)

An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia

por Swaroop, Alok, Oyer, Jon A., Will, Christine M., Huang, Xiaoxiao, Yu, Wenbo, Troche, Catalina, Bulic, Marinka, Durham, Benjamin H., Wen, Qiang Jeremy, Crispino, John D., MacKerell, Alexander D., Bennett, Richard L., Kelleher, Neil L., Licht, Jonathan D.
Publicado en Oncogene (2018)

Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms

por Wen, Qiang Jeremy, Yang, Qiong, Goldenson, Benjamin, Malinge, Sébastien, Lasho, Terra, Schneider, Rebekka K., Breyfogle, Lawrence J., Schultz, Rachael, Gilles, Laure, Koppikar, Priya, Abdel-Wahab, Omar, Pardanani, Animesh, Stein, Brady, Gurbuxani, Sandeep, Mullally, Ann, Levine, Ross, Tefferi, Ayalew, Crispino, John D.
Publicado en Nat Med (2015)

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

por Gilles, Laure, Arslan, Ahmet Dirim, Marinaccio, Christian, Wen, Qiang Jeremy, Arya, Priyanka, McNulty, Maureen, Yang, Qiong, Zhao, Jonathan C., Konstantinoff, Katerina, Lasho, Terra, Pardanani, Animesh, Stein, Brady, Plo, Isabelle, Sundaravel, Sriram, Wickrema, Amittha, Migliaccio, Annarita, Gurbuxani, Sandeep, Vainchenker, William, Platanias, Leonidas C., Tefferi, Ayalew, Crispino, John D.
Publicado en J Clin Invest (2017)

LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms

por Marinaccio, Christian, Suraneni, Praveen, Celik, Hamza, Volk, Andrew, Wen, Qiang Jeremy, Ling, Te, Bulic, Marinka, Lasho, Terra, Koche, Richard P., Famulare, Christopher A., Farnoud, Noushin, Stein, Brady, Schieber, Michael, Gurbuxani, Sandeep, Root, David E., Younger, Scott T., Hoffman, Ronald, Gangat, Naseema, Ntziachristos, Panagiotis, Chandel, Navdeep S., Levine, Ross L, Rampal, Raajit K., Challen, Grant A., Tefferi, Ayalew, Crispino, John D.
Publicado en Cancer Discov (2021)