Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34(+) cells, splenomegaly, and a propensity to evolve to acute myeloid leukemia. Moreover, the spleen and BM of patients harbor atypical, clustered megakaryocytes,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gilles, Laure, Arslan, Ahmet Dirim, Marinaccio, Christian, Wen, Qiang Jeremy, Arya, Priyanka, McNulty, Maureen, Yang, Qiong, Zhao, Jonathan C., Konstantinoff, Katerina, Lasho, Terra, Pardanani, Animesh, Stein, Brady, Plo, Isabelle, Sundaravel, Sriram, Wickrema, Amittha, Migliaccio, Annarita, Gurbuxani, Sandeep, Vainchenker, William, Platanias, Leonidas C., Tefferi, Ayalew, Crispino, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373858/
https://ncbi.nlm.nih.gov/pubmed/28240607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82905
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