Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34(+) cells, splenomegaly, and a propensity to evolve to acute myeloid leukemia. Moreover, the spleen and BM of patients harbor atypical, clustered megakaryocytes,...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Clin Invest
Κύριοι συγγραφείς: Gilles, Laure, Arslan, Ahmet Dirim, Marinaccio, Christian, Wen, Qiang Jeremy, Arya, Priyanka, McNulty, Maureen, Yang, Qiong, Zhao, Jonathan C., Konstantinoff, Katerina, Lasho, Terra, Pardanani, Animesh, Stein, Brady, Plo, Isabelle, Sundaravel, Sriram, Wickrema, Amittha, Migliaccio, Annarita, Gurbuxani, Sandeep, Vainchenker, William, Platanias, Leonidas C., Tefferi, Ayalew, Crispino, John D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2017
Θέματα:
Brief Report
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373858/
https://ncbi.nlm.nih.gov/pubmed/28240607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82905
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