Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34(+) cells, splenomegaly, and a propensity to evolve to acute myeloid leukemia. Moreover, the spleen and BM of patients harbor atypical, clustered megakaryocytes,...

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Pubblicato in:J Clin Invest
Autori principali: Gilles, Laure, Arslan, Ahmet Dirim, Marinaccio, Christian, Wen, Qiang Jeremy, Arya, Priyanka, McNulty, Maureen, Yang, Qiong, Zhao, Jonathan C., Konstantinoff, Katerina, Lasho, Terra, Pardanani, Animesh, Stein, Brady, Plo, Isabelle, Sundaravel, Sriram, Wickrema, Amittha, Migliaccio, Annarita, Gurbuxani, Sandeep, Vainchenker, William, Platanias, Leonidas C., Tefferi, Ayalew, Crispino, John D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373858/
https://ncbi.nlm.nih.gov/pubmed/28240607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82905
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