Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2(V617F)-positive myeloproliferative neoplasms

V617F driver mutation of JAK2 is the leading cause of the Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs). Although thrombosis is a leading cause of mortality and morbidity in MPNs, the mechanisms underlying their pathogenesis are unclear. Here, we identified pleckstrin-2 (Plek2...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhao, Baobing, Mei, Yang, Cao, Lan, Zhang, Jingxin, Sumagin, Ronen, Yang, Jing, Gao, Juehua, Schipma, Matthew J., Wang, Yanfeng, Thorsheim, Chelsea, Zhao, Liang, Stalker, Timothy, Stein, Brady, Wen, Qiang Jeremy, Crispino, John D., Abrams, Charles S., Ji, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749534/
https://ncbi.nlm.nih.gov/pubmed/29202466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94518
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