Transgenic expression of JAK2(V617F) causes myeloproliferative disorders in mice

The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter....

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Bibliographic Details
Main Authors: Xing, Shu, Wanting, Tina Ho, Zhao, Wanming, Ma, Junfeng, Wang, Shaofeng, Xu, Xuesong, Li, Qingshan, Fu, Xueqi, Xu, Mingjiang, Zhao, Zhizhuang Joe
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384138/
https://ncbi.nlm.nih.gov/pubmed/18334677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091579
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