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Transgenic expression of JAK2(V617F) causes myeloproliferative disorders in mice
The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter....
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2384138/ https://ncbi.nlm.nih.gov/pubmed/18334677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091579 |
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