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Transgenic expression of JAK2(V617F) causes myeloproliferative disorders in mice

The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xing, Shu, Wanting, Tina Ho, Zhao, Wanming, Ma, Junfeng, Wang, Shaofeng, Xu, Xuesong, Li, Qingshan, Fu, Xueqi, Xu, Mingjiang, Zhao, Zhizhuang Joe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384138/
https://ncbi.nlm.nih.gov/pubmed/18334677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091579
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