Transgenic expression of JAK2(V617F) causes myeloproliferative disorders in mice

The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter....

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Autori principali: Xing, Shu, Wanting, Tina Ho, Zhao, Wanming, Ma, Junfeng, Wang, Shaofeng, Xu, Xuesong, Li, Qingshan, Fu, Xueqi, Xu, Mingjiang, Zhao, Zhizhuang Joe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384138/
https://ncbi.nlm.nih.gov/pubmed/18334677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091579
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