Transgenic expression of JAK2(V617F) causes myeloproliferative disorders in mice

The JAK2(V617F) mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated transgenic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter....

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Detalhes bibliográficos
Main Authors: Xing, Shu, Wanting, Tina Ho, Zhao, Wanming, Ma, Junfeng, Wang, Shaofeng, Xu, Xuesong, Li, Qingshan, Fu, Xueqi, Xu, Mingjiang, Zhao, Zhizhuang Joe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384138/
https://ncbi.nlm.nih.gov/pubmed/18334677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091579
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