Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

The JAK2 mutation JAK2V617F is found frequently in patients with myeloproliferative disorders (MPD) and transforms hematopoietic cells to cytokine-independent proliferation when expressed with specific cytokine receptors. The Src homology 2 (SH2) and pleckstrin homology (PH) domain-containing adapto...

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Bibliographic Details
Main Authors: Gery, Sigal, Cao, Qi, Gueller, Saskia, Xing, Hongtao, Tefferi, Ayalew, Koeffler, H. Phillip
Format: Artigo
Language:Inglês
Published: The Society for Leukocyte Biology 2009
Subjects:
Receptors, Signal Transduction, and Genes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698587/
https://ncbi.nlm.nih.gov/pubmed/19293402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0908575
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