Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

The M-CSFR (c-Fms) participates in proliferation, differentiation, and survival of macrophages and is involved in the regulation of distinct macrophage functions. Interaction with the ligand M-CSF results in phosphorylation of tyrosine residues on c-Fms, thereby creating binding sites for molecules...

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Detalhes bibliográficos
Main Authors: Gueller, Saskia, Goodridge, Helen S., Niebuhr, Birte, Xing, Hongtao, Koren-Michowitz, Maya, Serve, Hubert, Underhill, David M., Brandts, Christian H., Koeffler, H. Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2010
Assuntos:
Receptors, Signal Transduction, & Genes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218676/
https://ncbi.nlm.nih.gov/pubmed/20571037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0309185
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