Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders

Recently, activating myeloproliferative leukemia virus oncogene (MPL) mutations, MPLW515L/K, were described in myeloproliferative disorder (MPD) patients. MPLW515L leads to activation of downstream signaling pathways and cytokine-independent proliferation in hematopoietic cells. The adaptor protein...

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Hlavní autoři: Gery, Sigal, Gueller, Saskia, Chumakova, Katya, Kawamata, Norihiko, Liu, Liqin, Koeffler, H. Phillip
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200920/
https://ncbi.nlm.nih.gov/pubmed/17693582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-089326
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