Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase with important roles in hematopoietic progenitor cell survival and proliferation. It is mutated in approximately one-third of AML patients, mostly by internal tandem duplications (ITDs). Adaptor protein Lnk is a negative regulator of he...

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Auteurs principaux: Lin, De-Chen, Yin, Tong, Koren-Michowitz, Maya, Ding, Ling-Wen, Gueller, Saskia, Gery, Sigal, Tabayashi, Takayuki, Bergholz, Ulla, Kazi, Julhash U., Rönnstrand, Lars, Stocking, Carol, Koeffler, H. Phillip
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476541/
https://ncbi.nlm.nih.gov/pubmed/22942183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388611
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