LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms

The myeloproliferative neoplasms frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of LKB1/Stk11 led to enhanced in vitro self-renewal...

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Publicat a:Cancer Discov
Autors principals: Marinaccio, Christian, Suraneni, Praveen, Celik, Hamza, Volk, Andrew, Wen, Qiang Jeremy, Ling, Te, Bulic, Marinka, Lasho, Terra, Koche, Richard P., Famulare, Christopher A., Farnoud, Noushin, Stein, Brady, Schieber, Michael, Gurbuxani, Sandeep, Root, David E., Younger, Scott T., Hoffman, Ronald, Gangat, Naseema, Ntziachristos, Panagiotis, Chandel, Navdeep S., Levine, Ross L, Rampal, Raajit K., Challen, Grant A., Tefferi, Ayalew, Crispino, John D.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178182/
https://ncbi.nlm.nih.gov/pubmed/33579786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1353
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