Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera

Por Mullally, Ann, Poveromo, Luke, Schneider, Rebekka K., Al-Shahrour, Fatima, Lane, Steven W., Ebert, Benjamin L.
Publicado em 2012

(R)-2-Hydroxyglutarate is Sufficient to Promote Leukemogenesis and its Effects are Reversible

Por Losman, Julie-Aurore, Looper, Ryan, Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn, Root, David, Ebert, Benjamin L., Kaelin, William G.
Publicado em 2013

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis

Por Kramann, Rafael, Schneider, Rebekka K., DiRocco, Derek P., Machado, Flavia, Fleig, Susanne, Bondzie, Philip A., Henderson, Joel M., Ebert, Benjamin L., Humphreys, Benjamin D.
Publicado no Cell Stem Cell (2014)

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Por Kowalczyk, Monika S., Tirosh, Itay, Heckl, Dirk, Rao, Tata Nageswara, Dixit, Atray, Haas, Brian J., Schneider, Rebekka K., Wagers, Amy J., Ebert, Benjamin L., Regev, Aviv
Publicado no Genome Res (2015)

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Por Chen, Edwin, Schneider, Rebekka K., Breyfogle, Lawrence J., Rosen, Emily A., Poveromo, Luke, Elf, Shannon, Ko, Amy, Brumme, Kristina, Levine, Ross, Ebert, Benjamin L., Mullally, Ann
Publicado no Blood (2015)

Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis

Por De Vita, Serena, Schneider, Rebekka K., Garcia, Michael, Wood, Jenna, Gavillet, Mathilde, Ebert, Benjamin L., Gerbaulet, Alexander, Roers, Axel, Levine, Ross L., Mullally, Ann, Williams, David A.
Publicado em 2014

Speckle Tracking Echocardiography Detects Uremic Cardiomyopathy Early and Predicts Cardiovascular Mortality in ESRD

Por Kramann, Rafael, Erpenbeck, Johanna, Schneider, Rebekka K., Röhl, Anna B., Hein, Marc, Brandenburg, Vincent M., van Diepen, Merel, Dekker, Friedo, Marx, Nicolaus, Floege, Jürgen, Becker, Michael, Schlieper, Georg
Publicado em 2014

Cell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells

Por Qin, Jie, Sontag, Stephanie, Lin, Qiong, Mitzka, Saskia, Leisten, Isabelle, Schneider, Rebekka K., Wang, Xiaoying, Jauch, Anna, Peitz, Michael, Brüstle, Oliver, Wagner, Wolfgang, Zhao, Robert Chunhua, Zenke, Martin
Publicado no Stem Cells Dev (2014)

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS

Por Schneider, Rebekka K., Ademà, Vera, Heckl, Dirk, Järås, Marcus, Mallo, Mar, Lord, Allegra M., Chu, Lisa P., McConkey, Marie E., Kramann, Rafael, Mullally, Ann, Bejar, Rafael, Solé, Francesc, Ebert, Benjamin L.
Publicado em 2014

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites

Por Ventura Ferreira, Mónica S., Bergmann, Christian, Bodensiek, Isabelle, Peukert, Kristina, Abert, Jessica, Kramann, Rafael, Kachel, Paul, Rath, Björn, Rütten, Stephan, Knuchel, Ruth, Ebert, Benjamin L., Fischer, Horst, Brümmendorf, Tim H., Schneider, Rebekka K.
Publicado no J Hematol Oncol (2016)

Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms

Por Schneider, Rebekka K, Ziegler, Susanne, Leisten, Isabelle, Ferreira, Monica SV, Schumacher, Anne, Rath, Björn, Fahrenkamp, Dirk, Müller-Newen, Gerhard, Crysandt, Martina, Wilop, Stefan, Jost, Edgar, Koschmieder, Steffen, Knüchel, Ruth, Brümmendorf, Tim H, Ziegler, Patrick
Publicado no J Hematol Oncol (2014)

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

Por Kramann, Rafael, Fleig, Susanne V., Schneider, Rebekka K., Fabian, Steven L., DiRocco, Derek P., Maarouf, Omar, Wongboonsin, Janewit, Ikeda, Yoichiro, Heckl, Dirk, Chang, Steven L., Rennke, Helmut G., Waikar, Sushrut S., Humphreys, Benjamin D.
Publicado no J Clin Invest (2015)

Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease

Por Kramann, Rafael, Goettsch, Claudia, Wongboonsin, Janewit, Iwata, Hiroshi, Schneider, Rebekka K, Kuppe, Christoph, Kaesler, Nadine, Chang-Panesso, Monica, Machado, Flavia G., Gratwohl, Susannah, Madhurima, Kaushal, Hutcheson, Joshua D., Jain, Sanjay, Aikawa, Elena, Humphreys, Benjamin D.
Publicado no Cell Stem Cell (2016)

Mutant calreticulin requires both its mutant C-terminus and the thrombopoietin receptor for oncogenic transformation

Por Elf, Shannon, Abdelfattah, Nouran S., Chen, Edwin, Perales-Patón, Javier, Rosen, Emily A., Ko, Amy, Peisker, Fabian, Florescu, Natalie, Giannini, Silvia, Wolach, Ofir, Morgan, Elizabeth A., Tothova, Zuzana, Losman, Julie-Aurore, Schneider, Rebekka K., Al-Shahrour, Fatima, Mullally, Ann
Publicado no Cancer Discov (2016)

Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms

Por Wen, Qiang Jeremy, Yang, Qiong, Goldenson, Benjamin, Malinge, Sébastien, Lasho, Terra, Schneider, Rebekka K., Breyfogle, Lawrence J., Schultz, Rachael, Gilles, Laure, Koppikar, Priya, Abdel-Wahab, Omar, Pardanani, Animesh, Stein, Brady, Gurbuxani, Sandeep, Mullally, Ann, Levine, Ross, Tefferi, Ayalew, Crispino, John D.
Publicado no Nat Med (2015)

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

Por Järås, Marcus, Miller, Peter G., Chu, Lisa P., Puram, Rishi V., Fink, Emma C., Schneider, Rebekka K., Al-Shahrour, Fatima, Peña, Pablo, Breyfogle, L. Jordan, Hartwell, Kimberly A., McConkey, Marie E., Cowley, Glenn S., Root, David E., Kharas, Michael G., Mullally, Ann, Ebert, Benjamin L.
Publicado em 2014

Core circadian clock genes regulate leukemia stem cells in AML

Por Puram, Rishi V., Kowalczyk, Monika S., de Boer, Carl G., Schneider, Rebekka K., Miller, Peter G., McConkey, Marie, Tothova, Zuzana, Tejero, Héctor, Heckl, Dirk, Järås, Marcus, Chen, Michelle C., Li, Hubo, Tamayo, Alfred, Cowley, Glenn S., Rozenblatt-Rosen, Orit, Al-Shahrour, Fatima, Regev, Aviv, Ebert, Benjamin L.
Publicado no Cell (2016)

Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9

Por Schneider, Rebekka K., Schenone, Monica, Ferreira, Monica Ventura, Kramann, Rafael, Joyce, Cailin E., Hartigan, Christina, Beier, Fabian, Brümmendorf, Tim H., Gehrming, Ulrich, Platzbecker, Uwe, Büsche, Guntram, Knüchel, Ruth, Chen, Michelle C., Waters, Christopher S., Chen, Edwin, Chu, Lisa P., Novina, Carl D., Lindsley, R. Coleman, Carr, Steven A., Ebert, Benjamin L.
Publicado no Nat Med (2016)

Physiologic expression of SF3B1(K700E) causes impaired erythropoiesis, aberrant splicing, and sensitivity to pharmacologic spliceosome modulation

Por Obeng, Esther A., Chappell, Ryan J., Seiler, Michael, Chen, Michelle C., Campagna, Dean R., Schmidt, Paul J., Schneider, Rebekka K., Lord, Allegra M., Wang, Lili, Gambe, Rutendo G., McConkey, Marie E., Ali, Abdullah M., Raza, Azra, Yu, Lihua, Buonamici, Silvia, Smith, Peter G., Mullally, Ann, Wu, Catherine J., Fleming, Mark D., Ebert, Benjamin L.
Publicado no Cancer Cell (2016)

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Por Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D.R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.
Publicado no Nature (2015)