Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera

In the current model of the pathogenesis of polycythemia vera (PV), the JAK2V617F mutation arises in hematopoietic stem cells (HSCs) that maintain the disease, while erythroid precursor populations expand, resulting in excessive red blood cell production. We examined the role of these specific cell...

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Detalhes bibliográficos
Main Authors: Mullally, Ann, Poveromo, Luke, Schneider, Rebekka K., Al-Shahrour, Fatima, Lane, Steven W., Ebert, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390954/
https://ncbi.nlm.nih.gov/pubmed/22627765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402396
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