Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Signaling mutations (eg, JAK2V617F) and mutations in genes involved in epigenetic regulation (eg, TET2) are the most common cooccurring classes of mutations in myeloproliferative neoplasms (MPNs). Clinical correlative studies have demonstrated that TET2 mutations are enriched in more advanced phases...

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Detalhes bibliográficos
Publicado no:Blood
Principais autores: Chen, Edwin, Schneider, Rebekka K., Breyfogle, Lawrence J., Rosen, Emily A., Poveromo, Luke, Elf, Shannon, Ko, Amy, Brumme, Kristina, Levine, Ross, Ebert, Benjamin L., Mullally, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287639/
https://ncbi.nlm.nih.gov/pubmed/25281607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-567024
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