Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

Interferon-α (IFNα) is an effective treatment of patients with myeloproliferative neoplasms (MPNs). In addition to inducing hematological responses in most MPN patients, IFNα reduces the JAK2V617F allelic burden and can render the JAK2V617F mutant clone undetectable in some patients. The precise mec...

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Hauptverfasser: Mullally, Ann, Bruedigam, Claudia, Poveromo, Luke, Heidel, Florian H., Purdon, Amy, Vu, Therese, Austin, Rebecca, Heckl, Dirk, Breyfogle, Lawrence J., Kuhn, Catherine Paine, Kalaitzidis, Demetrios, Armstrong, Scott A., Williams, David A., Hill, Geoff R., Ebert, Benjamin L., Lane, Steven W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643767/
https://ncbi.nlm.nih.gov/pubmed/23487027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-432989
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