Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Signaling mutations (eg, JAK2V617F) and mutations in genes involved in epigenetic regulation (eg, TET2) are the most common cooccurring classes of mutations in myeloproliferative neoplasms (MPNs). Clinical correlative studies have demonstrated that TET2 mutations are enriched in more advanced phases...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Chen, Edwin, Schneider, Rebekka K., Breyfogle, Lawrence J., Rosen, Emily A., Poveromo, Luke, Elf, Shannon, Ko, Amy, Brumme, Kristina, Levine, Ross, Ebert, Benjamin L., Mullally, Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287639/
https://ncbi.nlm.nih.gov/pubmed/25281607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-567024
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