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The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

Although a large proportion of patients with polycythemia vera (PV) harbor a valine-to-phenylalanine mutation at amino acid 617 (V617F) in the JAK2 signaling molecule, the stage of hematopoiesis at which the mutation arises is unknown. Here we isolated and characterized hematopoietic stem cells (HSC...

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Main Authors: Jamieson, Catriona H. M., Gotlib, Jason, Durocher, Jeffrey A., Chao, Mark P., Mariappan, M. Rajan, Lay, Marla, Jones, Carol, Zehnder, James L., Lilleberg, Stan L., Weissman, Irving L.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1434515/
https://ncbi.nlm.nih.gov/pubmed/16603627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601462103
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