The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

Although a large proportion of patients with polycythemia vera (PV) harbor a valine-to-phenylalanine mutation at amino acid 617 (V617F) in the JAK2 signaling molecule, the stage of hematopoiesis at which the mutation arises is unknown. Here we isolated and characterized hematopoietic stem cells (HSC...

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Bibliographic Details
Main Authors: Jamieson, Catriona H. M., Gotlib, Jason, Durocher, Jeffrey A., Chao, Mark P., Mariappan, M. Rajan, Lay, Marla, Jones, Carol, Zehnder, James L., Lilleberg, Stan L., Weissman, Irving L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1434515/
https://ncbi.nlm.nih.gov/pubmed/16603627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601462103
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