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In Vitro Expansion of Erythroid Progenitors from Polycythemia Vera Patients Leads to Decrease in JAK2(V617F) Allele
OBJECTIVES: A G>T transversion in a tyrosine kinase JAK2 (V617F) was reported in over 80% of patients with polycythemia vera (PV). Current evidence suggests that JAK2(V617F) somatic mutation is involved in the pathogenesis of PV, since it confers erythropoietin independent proliferation to erythr...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1931508/ https://ncbi.nlm.nih.gov/pubmed/17379069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2006.12.007 |
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