In Vitro Expansion of Erythroid Progenitors from Polycythemia Vera Patients Leads to Decrease in JAK2(V617F) Allele

OBJECTIVES: A G>T transversion in a tyrosine kinase JAK2 (V617F) was reported in over 80% of patients with polycythemia vera (PV). Current evidence suggests that JAK2(V617F) somatic mutation is involved in the pathogenesis of PV, since it confers erythropoietin independent proliferation to erythr...

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Bibliographic Details
Main Authors: Gaikwad, Amos, Nussenzveig, Roberto, Liu, Enli, Gottshalk, Stephen, Chang, KoTung, Prchal, Josef T.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1931508/
https://ncbi.nlm.nih.gov/pubmed/17379069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2006.12.007
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