The JAK kinase inhibitor CP‐690,550 supresses the growth of human polycythemia vera cells carrying the JAK2(V617F) mutation

The somatic activating janus kinase 2 mutation (JAK2)(V617F) is detectable in most patients with polycythemia vera (PV). Here we report that CP‐690,550 exerts greater antiproliferative and pro‐apoptotic activity against cells harboring JAK2(V617F) compared with JAK2(WT). CP‐690,550 treatment of muri...

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發表在:Cancer Sci
Main Authors: Manshouri, Taghi, Quintás‐Cardama, Alfonso, Nussenzveig, Roberto H., Gaikwad, Amos, Estrov, Zeev, Prchal, Josef, Cortes, Jorge E., Kantarjian, Hagop M., Verstovsek, Srdan
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Asia 2008
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Original Articles/Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829954/
https://ncbi.nlm.nih.gov/pubmed/18482053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2008.00817.x
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