The JAK kinase inhibitor CP‐690,550 supresses the growth of human polycythemia vera cells carrying the JAK2(V617F) mutation

The somatic activating janus kinase 2 mutation (JAK2)(V617F) is detectable in most patients with polycythemia vera (PV). Here we report that CP‐690,550 exerts greater antiproliferative and pro‐apoptotic activity against cells harboring JAK2(V617F) compared with JAK2(WT). CP‐690,550 treatment of muri...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Sci
Auteurs principaux: Manshouri, Taghi, Quintás‐Cardama, Alfonso, Nussenzveig, Roberto H., Gaikwad, Amos, Estrov, Zeev, Prchal, Josef, Cortes, Jorge E., Kantarjian, Hagop M., Verstovsek, Srdan
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Asia 2008
Sujets:
Original Articles/Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829954/
https://ncbi.nlm.nih.gov/pubmed/18482053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2008.00817.x
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