Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+ )T lymphocyte cytokine production

BACKGROUND: The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4(+ )T cells. RESULTS: CD4(+ )T cells produced IL-2, IL-4, IL-17, I...

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Détails bibliographiques
Auteurs principaux: Migita, Kiyoshi, Miyashita, Taiichiro, Izumi, Yasumori, Koga, Tomohiro, Komori, Atsumasa, Maeda, Yumi, Jiuchi, Yuka, Aiba, Yoshihiro, Yamasaki, Satoshi, Kawakami, Atsushi, Nakamura, Minoru, Ishibashi, Hiromi
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179939/
https://ncbi.nlm.nih.gov/pubmed/21884580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-51
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