Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+ )T lymphocyte cytokine production

BACKGROUND: The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4(+ )T cells. RESULTS: CD4(+ )T cells produced IL-2, IL-4, IL-17, I...

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Bibliografiske detaljer
Main Authors: Migita, Kiyoshi, Miyashita, Taiichiro, Izumi, Yasumori, Koga, Tomohiro, Komori, Atsumasa, Maeda, Yumi, Jiuchi, Yuka, Aiba, Yoshihiro, Yamasaki, Satoshi, Kawakami, Atsushi, Nakamura, Minoru, Ishibashi, Hiromi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179939/
https://ncbi.nlm.nih.gov/pubmed/21884580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-51
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