Serum amyloid A triggers the mosodium urate -mediated mature interleukin-1β production from human synovial fibroblasts

BACKGROUND: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1β (IL-1β) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. In...

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Autors principals: Migita, Kiyoshi, Koga, Tomohiro, Satomura, Kenshi, Izumi, Masahiro, Torigoshi, Takafumi, Maeda, Yumi, Izumi, Yasumori, Jiuchi, Yuka, Miyashita, Taiichiro, Yamasaki, Satoshi, Aiba, Yoshihiro, Komori, Atsumasa, Nakamura, Minoru, Motokawa, Satoru, Kawakami, Atsushi, Nakamura, Tadashi, Ishibashi, Hiromi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446500/
https://ncbi.nlm.nih.gov/pubmed/22608202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3849
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