CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes

INTRODUCTION: Interleukin (IL)-6-type cytokines exert their effects through activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade. The JAK/STAT pathways play an important role in rheumatoid arthritis, since JAK inhibitors have exhibited dramat...

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Bibliographic Details
Main Authors: Migita, Kiyoshi, Komori, Atsumasa, Torigoshi, Takafumi, Maeda, Yumi, Izumi, Yasumori, Jiuchi, Yuka, Miyashita, Taiichiro, Nakamura, Minoru, Motokawa, Satoru, Ishibashi, Hiromi
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218881/
https://ncbi.nlm.nih.gov/pubmed/21548952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3333
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