Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Inhibitors of the JAK family of non-receptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise mechanisms by which JAK inhibition improves inflammatory immune responses remain unclear. Here we examined the mode of acti...

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Hlavní autoři: Ghoreschi, Kamran, Jesson, Michael I., Li, Xiong, Lee, Jamie L., Ghosh, Sarbani, Alsup, Jason W., Warner, James D., Tanaka, Masao, Steward-Tharp, Scott M., Gadina, Massimo, Thomas, Craig, Minnerly, John C., Storer, Chad E., LaBranche, Timothy P., Radi, Zaher A., Dowty, Martin E., Head, Richard D., Meyer, Debra M., Kishore, Nandini, O'Shea, John J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108067/
https://ncbi.nlm.nih.gov/pubmed/21383241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003668
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