Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Inhibitors of the JAK family of non-receptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders; however, the precise mechanisms by which JAK inhibition improves inflammatory immune responses remain unclear. Here we examined the mode of acti...

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Bibliografiske detaljer
Main Authors: Ghoreschi, Kamran, Jesson, Michael I., Li, Xiong, Lee, Jamie L., Ghosh, Sarbani, Alsup, Jason W., Warner, James D., Tanaka, Masao, Steward-Tharp, Scott M., Gadina, Massimo, Thomas, Craig, Minnerly, John C., Storer, Chad E., LaBranche, Timothy P., Radi, Zaher A., Dowty, Martin E., Head, Richard D., Meyer, Debra M., Kishore, Nandini, O'Shea, John J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108067/
https://ncbi.nlm.nih.gov/pubmed/21383241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003668
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