Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populat...

af Tse, Susanna, Dowty, Martin E., Menon, Sujatha, Gupta, Pankaj, Krishnaswami, Sriram
Udgivet i J Clin Pharmacol (2020)

Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

af Gupta, Pankaj, Alvey, Christine, Wang, Rong, Dowty, Martin E, Fahmi, Odette A, Walsky, Robert L, Riese, Richard J, Krishnaswami, Sriram
Udgivet 2012

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

af Dowty, Martin E., Lin, Tsung H., Jesson, Michael I., Hegen, Martin, Martin, David A., Katkade, Vaibhav, Menon, Sujatha, Telliez, Jean‐Baptiste
Udgivet i Pharmacol Res Perspect (2019)

Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF‐06826647: A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Dose‐Escalation Study

af Singh, Ravi Shankar P., Pradhan, Vivek, Roberts, Erika S., Scaramozza, Matthew, Kieras, Elizabeth, Gale, Jeremy D., Peeva, Elena, Vincent, Michael S., Banerjee, Anindita, Fensome, Andrew, Dowty, Martin E., Winkle, Peter, Tehlirian, Christopher
Udgivet i Clin Transl Sci (2020)

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

af Gerstenberger, Brian S., Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Fensome, Andrew, Gifford, Roger, Griffor, Matthew C., Hegen, Martin, Hollingshead, Brett D., Knafels, John D., Lin, Tsung H., Smith, James F., Vajdos, Felix F.
Udgivet i Sci Rep (2020)

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

af Avery, Lindsay B., Wang, Mengmeng, Kavosi, Mania S., Joyce, Alison, Kurz, Jeffrey C., Fan, Yao-Yun, Dowty, Martin E., Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M., Neubert, Hendrik, Polzer, Robert J., O'Hara, Denise M.
Udgivet i MAbs (2016)

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

af Meyer Debra M, Jesson Michael I, Li Xiong, Elrick Mollisa M, Funckes-Shippy Christie L, Warner James D, Gross Cindy J, Dowty Martin E, Ramaiah Shashi K, Hirsch Jeffrey L, Saabye Matthew J, Barks Jennifer L, Kishore Nandini, Morris Dale L
Udgivet 2010-08-01

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

af Meyer, Debra M, Jesson, Michael I, Li, Xiong, Elrick, Mollisa M, Funckes-Shippy, Christie L, Warner, James D, Gross, Cindy J, Dowty, Martin E, Ramaiah, Shashi K, Hirsch, Jeffrey L, Saabye, Matthew J, Barks, Jennifer L, Kishore, Nandini, Morris, Dale L
Udgivet 2010

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

af Ghoreschi, Kamran, Jesson, Michael I., Li, Xiong, Lee, Jamie L., Ghosh, Sarbani, Alsup, Jason W., Warner, James D., Tanaka, Masao, Steward-Tharp, Scott M., Gadina, Massimo, Thomas, Craig, Minnerly, John C., Storer, Chad E., LaBranche, Timothy P., Radi, Zaher A., Dowty, Martin E., Head, Richard D., Meyer, Debra M., Kishore, Nandini, O'Shea, John J.
Udgivet 2011

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

af Carron, Chris P., Trujillo, John I., Olson, Kirk L., Huang, Wei, Hamper, Bruce C., Dice, Tom, Neal, Bradley E., Pelc, Matthew J., Day, Jacqueline E., Rohrer, Douglas C., Kiefer, James R., Moon, Joseph B., Schweitzer, Barbara A., Blake, Tanisha D., Turner, Steve R., Woerndle, Rhonda, Case, Brenda L., Bono, Christine P., Dilworth, Vickie M., Funckes-Shippy, Christie L., Hood, Becky L., Jerome, Gina M., Kornmeier, Christine M., Radabaugh, Melissa R., Williams, Melanie L., Davies, Michael S., Wegner, Craig D., Welsch, Dean J., Abraham, William M., Warren, Chad J., Dowty, Martin E., Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z., Thorarensen, Atli
Udgivet 2010