Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro data

Por Gupta, Pankaj, Alvey, Christine, Wang, Rong, Dowty, Martin E, Fahmi, Odette A, Walsky, Robert L, Riese, Richard J, Krishnaswami, Sriram
Publicado em 2012

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

Por Avery, Lindsay B., Wang, Mengmeng, Kavosi, Mania S., Joyce, Alison, Kurz, Jeffrey C., Fan, Yao-Yun, Dowty, Martin E., Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M., Neubert, Hendrik, Polzer, Robert J., O'Hara, Denise M.
Publicado no MAbs (2016)

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Por Meyer Debra M, Jesson Michael I, Li Xiong, Elrick Mollisa M, Funckes-Shippy Christie L, Warner James D, Gross Cindy J, Dowty Martin E, Ramaiah Shashi K, Hirsch Jeffrey L, Saabye Matthew J, Barks Jennifer L, Kishore Nandini, Morris Dale L
Publicado em 2010-08-01

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Por Meyer, Debra M, Jesson, Michael I, Li, Xiong, Elrick, Mollisa M, Funckes-Shippy, Christie L, Warner, James D, Gross, Cindy J, Dowty, Martin E, Ramaiah, Shashi K, Hirsch, Jeffrey L, Saabye, Matthew J, Barks, Jennifer L, Kishore, Nandini, Morris, Dale L
Publicado em 2010

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Por Ghoreschi, Kamran, Jesson, Michael I., Li, Xiong, Lee, Jamie L., Ghosh, Sarbani, Alsup, Jason W., Warner, James D., Tanaka, Masao, Steward-Tharp, Scott M., Gadina, Massimo, Thomas, Craig, Minnerly, John C., Storer, Chad E., LaBranche, Timothy P., Radi, Zaher A., Dowty, Martin E., Head, Richard D., Meyer, Debra M., Kishore, Nandini, O'Shea, John J.
Publicado em 2011

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

Por Carron, Chris P., Trujillo, John I., Olson, Kirk L., Huang, Wei, Hamper, Bruce C., Dice, Tom, Neal, Bradley E., Pelc, Matthew J., Day, Jacqueline E., Rohrer, Douglas C., Kiefer, James R., Moon, Joseph B., Schweitzer, Barbara A., Blake, Tanisha D., Turner, Steve R., Woerndle, Rhonda, Case, Brenda L., Bono, Christine P., Dilworth, Vickie M., Funckes-Shippy, Christie L., Hood, Becky L., Jerome, Gina M., Kornmeier, Christine M., Radabaugh, Melissa R., Williams, Melanie L., Davies, Michael S., Wegner, Craig D., Welsch, Dean J., Abraham, William M., Warren, Chad J., Dowty, Martin E., Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z., Thorarensen, Atli
Publicado em 2010