Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds

Janus kinase (JAK) inhibitors have been developed as anti-inflammatory agents and have demonstrated clinical efficacy in rheumatoid arthritis (RA). We investigated if JAK-3-selective inhibition alone could disrupt cytokine signalling in rheumatoid synovial fibroblasts. In-vitro studies were performe...

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Detalhes bibliográficos
Main Authors: Migita, K, Izumi, Y, Torigoshi, T, Satomura, K, Izumi, M, Nishino, Y, Jiuchi, Y, Nakamura, M, Kozuru, H, Nonaka, F, Eguchi, K, Kawakami, A, Motokawa, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826302/
https://ncbi.nlm.nih.gov/pubmed/23968543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12190
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