BONE MARROW STROMA SECRETED CYTOKINES PROTECT JAK2(V617F)-MUTATED CELLS FROM THE EFFECTS OF A JAK2 INHIBITOR

Signals emanating from the bone marrow microenvironment, including stromal cells, are thought to support the survival and proliferation of the malignant cells in patients with myeloproliferative neoplasms (MPN). To examine this hypothesis we established a co-culture platform (cells co-cultured direc...

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Detalhes bibliográficos
Main Authors: Manshouri, Taghi, Estrov, Zeev, Quintás-Cardama, Alfonso, Burger, Jan, Zhang, Ying, Livun, Ana, Knez, Liza, Harris, David, Creighton, Chad J., Kantarjian, Hagop M., Verstovsek, Srdan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067142/
https://ncbi.nlm.nih.gov/pubmed/21512135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4002
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