THERAPY WITH THE HISTONE DEACETYLASE INHIBITOR PRACINOSTAT FOR PATIENTS WITH MYELOFIBROSIS

Approximately half of the patients with myelofibrosis (MF) carry mutant JAK2(V617F) proteins. JAK2(V617F) has been recently shown to translocate to the nucleus and modify specific histones, thus regulating transcription. We report on a phase II study testing the activity and tolerability of the hist...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Quintás-Cardama, Alfonso, Kantarjian, Hagop, Estrov, Zeev, Borthakur, Gautam, Cortes, Jorge, Verstovsek, Srdan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152772/
https://ncbi.nlm.nih.gov/pubmed/22475363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.03.003
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi