THERAPY WITH THE HISTONE DEACETYLASE INHIBITOR PRACINOSTAT FOR PATIENTS WITH MYELOFIBROSIS

Approximately half of the patients with myelofibrosis (MF) carry mutant JAK2(V617F) proteins. JAK2(V617F) has been recently shown to translocate to the nucleus and modify specific histones, thus regulating transcription. We report on a phase II study testing the activity and tolerability of the hist...

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Main Authors: Quintás-Cardama, Alfonso, Kantarjian, Hagop, Estrov, Zeev, Borthakur, Gautam, Cortes, Jorge, Verstovsek, Srdan
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152772/
https://ncbi.nlm.nih.gov/pubmed/22475363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2012.03.003
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