Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from t...

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Vydáno v:Genome Res
Hlavní autoři: Kowalczyk, Monika S., Tirosh, Itay, Heckl, Dirk, Rao, Tata Nageswara, Dixit, Atray, Haas, Brian J., Schneider, Rebekka K., Wagers, Amy J., Ebert, Benjamin L., Regev, Aviv
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665007/
https://ncbi.nlm.nih.gov/pubmed/26430063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.192237.115
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