Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from t...

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Опубликовано в: :Genome Res
Главные авторы: Kowalczyk, Monika S., Tirosh, Itay, Heckl, Dirk, Rao, Tata Nageswara, Dixit, Atray, Haas, Brian J., Schneider, Rebekka K., Wagers, Amy J., Ebert, Benjamin L., Regev, Aviv
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2015
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4665007/
https://ncbi.nlm.nih.gov/pubmed/26430063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.192237.115
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