(R)-2-Hydroxyglutarate is Sufficient to Promote Leukemogenesis and its Effects are Reversible

IDH1 and IDH2 (Isocitrate Dehydrogenase 1 and 2) mutants are common in several cancers, including leukemias, and overproduce the (R)-enantiomer of 2-hydroxyglutarate [(R)-2-HG]. Elucidating the role of IDH mutations and (R)-2-HG in leukemogenesis has been hampered by a lack of appropriate cell-based...

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Bibliographic Details
Main Authors: Losman, Julie-Aurore, Looper, Ryan, Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn, Root, David, Ebert, Benjamin L., Kaelin, William G.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836459/
https://ncbi.nlm.nih.gov/pubmed/23393090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231677
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