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(R)-2-Hydroxyglutarate is Sufficient to Promote Leukemogenesis and its Effects are Reversible
IDH1 and IDH2 (Isocitrate Dehydrogenase 1 and 2) mutants are common in several cancers, including leukemias, and overproduce the (R)-enantiomer of 2-hydroxyglutarate [(R)-2-HG]. Elucidating the role of IDH mutations and (R)-2-HG in leukemogenesis has been hampered by a lack of appropriate cell-based...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836459/ https://ncbi.nlm.nih.gov/pubmed/23393090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1231677 |
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