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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the interconversion of isocitrate and 2-oxoglutarate (2OG). 2OG is a TCA cycle intermediate and an essential cofactor for man...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650222/ https://ncbi.nlm.nih.gov/pubmed/23630074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.217406.113 |
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