Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

BACKGROUND. Recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, which are frequent in gliomas, result in marked accumulation of the metabolic by-product 2-hydroxyglutarate (2-HG) within tumors. In other malignancies, such as acute myeloid leukemia, presence of IDH mutation i...

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Detalhes bibliográficos
Publicado no:Oncologist
Main Authors: Fathi, Amir T., Nahed, Brian V., Wander, Seth A., Iafrate, A. John, Borger, Darrell R., Hu, Ranliang, Thabet, Ashraf, Cahill, Daniel P., Perry, Ashley M., Joseph, Christelle P., Muzikansky, Alona, Chi, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2016
Assuntos:
Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746092/
https://ncbi.nlm.nih.gov/pubmed/26834160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0342
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