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Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma
BACKGROUND. Recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, which are frequent in gliomas, result in marked accumulation of the metabolic by-product 2-hydroxyglutarate (2-HG) within tumors. In other malignancies, such as acute myeloid leukemia, presence of IDH mutation i...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Oncologist |
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Κύριοι συγγραφείς: | , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
AlphaMed Press
2016
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746092/ https://ncbi.nlm.nih.gov/pubmed/26834160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0342 |
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