Non-invasive quantification of 2-hydroxyglutarate in human gliomas with IDH1 and IDH2 mutations

Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas where they are associated with abnormal accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Monitoring 2-HG levels could provide prognostic information in this disease, but detection strategies that are...

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Bibliografische gegevens
Gepubliceerd in:Cancer Res
Hoofdauteurs: Emir, Uzay E, Larkin, Sarah J, de Pennington, Nick, Voets, Natalie, Plaha, Puneet, Stacey, Richard, Al-Qahtani, Khalid, Mccullagh, James, Schofield, Christopher J, Clare, Stuart, Jezzard, Peter, Cadoux-Hudson, Tom, Ansorge, Olaf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704134/
https://ncbi.nlm.nih.gov/pubmed/26669865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0934
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