Treatment response assessment in IDH-mutant glioma patients by non-invasive 3D functional Spectroscopic Mapping of 2-Hydroxyglutarate

PURPOSE: Measurements of objective response rates are critical to evaluate new glioma therapies. The hallmark metabolic alteration in gliomas with mutant isocitrate dehydrogenase (IDH) is the overproduction of oncometabolite 2-hydroxyglutarate (2HG), which plays a key role in malignant transformatio...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Andronesi, Ovidiu C., Loebel, Franziska, Bogner, Wolfgang, Marjaǹska, Małgorzata, Vander Heiden, Matthew G., Iafrate, A. John, Dietrich, Jorg, Batchelor, Tracy T., Gerstner, Elizabeth R., Kaelin, William G., Chi, Andrew S., Rosen, Bruce R., Cahill, Daniel P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818725/
https://ncbi.nlm.nih.gov/pubmed/26534967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0656
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