Treatment response assessment in IDH-mutant glioma patients by non-invasive 3D functional Spectroscopic Mapping of 2-Hydroxyglutarate

PURPOSE: Measurements of objective response rates are critical to evaluate new glioma therapies. The hallmark metabolic alteration in gliomas with mutant isocitrate dehydrogenase (IDH) is the overproduction of oncometabolite 2-hydroxyglutarate (2HG), which plays a key role in malignant transformatio...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Andronesi, Ovidiu C., Loebel, Franziska, Bogner, Wolfgang, Marjaǹska, Małgorzata, Vander Heiden, Matthew G., Iafrate, A. John, Dietrich, Jorg, Batchelor, Tracy T., Gerstner, Elizabeth R., Kaelin, William G., Chi, Andrew S., Rosen, Bruce R., Cahill, Daniel P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818725/
https://ncbi.nlm.nih.gov/pubmed/26534967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0656
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