Detection of 2-Hydroxyglutarate in IDH-mutated Glioma Patients by Spectral-editing and 2D Correlation Magnetic Resonance Spectroscopy

Mutations of arginine 132 (R132) in the enzyme isocitrate dehydrogenase-1 (IDH1) are present in up to 86% of grade II and III gliomas and secondary glioblastoma. R132 mutations in IDH1 result in excess production of the metabolite 2-hydroxyglutarate (2HG), which could be used as a biomarker for this...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Andronesi, Ovidiu C., Kim, Grace, Gerstner, Elizabeth, Batchelor, Tracy, Tzika, Aria A., Fantin, Valeria R., Heiden, Matthew G. Vander, Sorensen, A. Gregory
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720836/
https://ncbi.nlm.nih.gov/pubmed/22238332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002693
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