Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central...

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Detalhes bibliográficos
Main Authors: Andronesi, Ovidiu C., Rapalino, Otto, Gerstner, Elizabeth, Chi, Andrew, Batchelor, Tracy T., Cahill, Dan P., Sorensen, A. Gregory, Rosen, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Review Series
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754248/
https://ncbi.nlm.nih.gov/pubmed/23999439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67229
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