2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1, 2) have been demonstrated in the majority of World Health Organization grade 2 and grade 3 gliomas in adults. These mutations are associated with the accumulation of 2-hydroxyglutarate (2HG) within the tumor. Here we report the noninvasive detecti...

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Hlavní autoři: Choi, Changho, Ganji, Sandeep K., DeBerardinis, Ralph J., Hatanpaa, Kimmo J., Rakheja, Dinesh, Kovacs, Zoltan, Yang, Xiao-Li, Mashimo, Tomoyuki, Raisanen, Jack M., Marin-Valencia, Isaac, Pascual, Juan M., Madden, Christopher J., Mickey, Bruce E., Malloy, Craig M., Bachoo, Robert, Maher, Elizabeth A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615719/
https://ncbi.nlm.nih.gov/pubmed/22281806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2682
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