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2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1, 2) have been demonstrated in the majority of World Health Organization grade 2 and grade 3 gliomas in adults. These mutations are associated with the accumulation of 2-hydroxyglutarate (2HG) within the tumor. Here we report the noninvasive detecti...
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| Auteurs principaux: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615719/ https://ncbi.nlm.nih.gov/pubmed/22281806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2682 |
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