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Conditions for (13)C NMR Detection of 2-Hydroxyglutarate in Tissue Extracts from IDH-Mutated Gliomas
(13)C NMR spectroscopy of extracts from patient tumor samples provides rich information about metabolism. However, in IDH-mutant gliomas (13)C labeling is obscured in glutamate and glutamine by the oncometabolite, 2-hydroxyglutaric acid (2HG), prompting development of a simple method to resolve the...
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| Publicado no: | Anal Biochem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458399/ https://ncbi.nlm.nih.gov/pubmed/25908561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2015.04.017 |
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