Conditions for (13)C NMR Detection of 2-Hydroxyglutarate in Tissue Extracts from IDH-Mutated Gliomas

(13)C NMR spectroscopy of extracts from patient tumor samples provides rich information about metabolism. However, in IDH-mutant gliomas (13)C labeling is obscured in glutamate and glutamine by the oncometabolite, 2-hydroxyglutaric acid (2HG), prompting development of a simple method to resolve the...

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Pubblicato in:Anal Biochem
Autori principali: Pichumani, Kumar, Mashimo, Tomoyuki, Baek, Hyeon-Man, Ratnakar, James, Mickey, Bruce, DeBerardinis, Ralph J., Maher, Elizabeth A., Bachoo, Robert M., Malloy, Craig R., Kovacs, Zoltan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458399/
https://ncbi.nlm.nih.gov/pubmed/25908561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2015.04.017
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