Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

BACKGROUND. Recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, which are frequent in gliomas, result in marked accumulation of the metabolic by-product 2-hydroxyglutarate (2-HG) within tumors. In other malignancies, such as acute myeloid leukemia, presence of IDH mutation i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Oncologist
Autores principales: Fathi, Amir T., Nahed, Brian V., Wander, Seth A., Iafrate, A. John, Borger, Darrell R., Hu, Ranliang, Thabet, Ashraf, Cahill, Daniel P., Perry, Ashley M., Joseph, Christelle P., Muzikansky, Alona, Chi, Andrew S.
Formato: Artigo
Lenguaje:Inglês
Publicado: AlphaMed Press 2016
Materias:
Neuro-Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746092/
https://ncbi.nlm.nih.gov/pubmed/26834160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0342
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares