Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

BACKGROUND. Recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, which are frequent in gliomas, result in marked accumulation of the metabolic by-product 2-hydroxyglutarate (2-HG) within tumors. In other malignancies, such as acute myeloid leukemia, presence of IDH mutation i...

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Dades bibliogràfiques
Publicat a:Oncologist
Autors principals: Fathi, Amir T., Nahed, Brian V., Wander, Seth A., Iafrate, A. John, Borger, Darrell R., Hu, Ranliang, Thabet, Ashraf, Cahill, Daniel P., Perry, Ashley M., Joseph, Christelle P., Muzikansky, Alona, Chi, Andrew S.
Format: Artigo
Idioma:Inglês
Publicat: AlphaMed Press 2016
Matèries:
Neuro-Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746092/
https://ncbi.nlm.nih.gov/pubmed/26834160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0342
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