Isocitrate Dehydrogenase 1 (IDH1) Mutation in Breast Adenocarcinoma Is Associated With Elevated Levels of Serum and Urine 2-Hydroxyglutarate

Mutations in the IDH1 and IDH2 (isocitrate dehydrogenase) genes have been discovered across a range of solid-organ and hematologic malignancies, including acute myeloid leukemia, glioma, chondrosarcoma, and cholangiocarcinoma. An intriguing aspect of IDH-mutant tumors is the aberrant production and...

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Hlavní autoři: Fathi, Amir T., Sadrzadeh, Hossein, Comander, Amy H., Higgins, Michaela J., Bardia, Aditya, Perry, Ashley, Burke, Meghan, Silver, Regina, Matulis, Christina R., Straley, Kimberly S., Yen, Katharine E., Agresta, Sam, Kim, Hyeryun, Schenkein, David P., Borger, Darrell R.
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2014
Témata:
Breast Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041671/
https://ncbi.nlm.nih.gov/pubmed/24760710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2013-0417
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